_This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
Small Molecule Interactions
It was very difficult to find small molecules that interact directly with HLA-C. Currently there are no drugs that target HLA-C (or MHC class 1 molecules) directly; however, drugs have targeted other proteins that can control HLA-C/MHC class 1 expression. There are small molecules which interact with proteins from HLA-C's protein-protein interactions (interactome); this, in turn, helps control the inflammation immune response.
Vitamin D3
http://www.rspharmchem.com/vitamin-d3.htm
Studies have shown that vitamin D3 helps treat psoriasis plaque symptoms. One major player in this response is the protein inter-leukin 2 (IL2). IL2 (Interleukin 2) is a cytokine (signalling molecule) released in T-cells when HLA-C/MHC class 1 presents antigens to the T cells. When IL2 is released a immune response is triggered creating an increase in cell proliferation. Vitamin D3 has been shown to suppress IL2 expression, thus decreasing cell proliferation and reducing psoriatic plaques.
References
1. Genestier L, Paillot R, Bonnefoy-Berard N, Waldmann H, Revillard JP. T cell sensitivity to HLA class I-mediated apoptosis is dependent on interleukin-2 and interleukin-4. Eur J Immunol. 1997 Feb;27(2):495-9.
2. Bemiss CJ, Mahon BD, Henry A, Weaver V, Cantorna MT Interleukin-2 is one of the targets of 1,25-dihydroxyvitamin D3 in the immune system. Arch Biochem Biophys. 2002 Jun 15;402(2):249-54.
3. Fleischer A et al. ITM2B regulates apoptosis by inducing loss of mitochondrial membrane potential. European Journal of Immunology 32(12): 3498-3505 (2002).
2. Bemiss CJ, Mahon BD, Henry A, Weaver V, Cantorna MT Interleukin-2 is one of the targets of 1,25-dihydroxyvitamin D3 in the immune system. Arch Biochem Biophys. 2002 Jun 15;402(2):249-54.
3. Fleischer A et al. ITM2B regulates apoptosis by inducing loss of mitochondrial membrane potential. European Journal of Immunology 32(12): 3498-3505 (2002).
_Site created by Valeri Lapacek
Genetics 677 Assignment, Spring 2012
University of Wisconsin-Madison
Last Updated: 5/23/2012
Genetics 677 Assignment, Spring 2012
University of Wisconsin-Madison
Last Updated: 5/23/2012