This web page was produced as an assignment for Genetics 677, an undergraduate course at UW-Madison.
What is gene ontology?
Gene ontology describes the biological processes, molecular functions, and cellular components involved with a gene/gene product (1,2,3,4). Given the advancement in biotechnology, protein data and analysis has escalated; standardized protein descriptions are necessary for consistent data representation. Gene ontology provides a controlled vocabulary which describes gene product properties and their relationships within the cell.
The Gene Ontology Consortium have created uniform vocabulary terms and gene annotations, called GO terms. A protein's GO terms are available using the AmiGO database, which groups terms into three categories: biological processes, molecular functions, and cellular components.
The Gene Ontology Consortium have created uniform vocabulary terms and gene annotations, called GO terms. A protein's GO terms are available using the AmiGO database, which groups terms into three categories: biological processes, molecular functions, and cellular components.
HLA-C Gene Ontology
HLA-C gene ontology data was provided by AmiGO. Click here to view the AmiGO result list.
This figure is an example of the graphical view of a HLA-C biological process (antigen processing and presentation of peptide antigen via MHC class I) created by AmiGO.
Cellular Components
This figure is an example of the graphical view of a HLA-C biological process (antigen processing and presentation of peptide antigen via MHC class I) created by AmiGO.
Cellular Components
- early endosome membrane
- ER to Golgi transport vesicle membrane
- Golgi membrane
- integral to lumenal side of endoplasmic reticulum membrane
- antigen processing and presentation
- antigen processing and presentation of exogenous peptide antigen via MHC class I
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
- antigen processing and presentation of peptide antigen via MHC class I
- cytokine-mediated signaling pathway
- interferon-gamma-mediated signaling pathway
- interspecies interaction between organisms
References
1. The Gene Ontology Consortium. (2008). The gene ontology project in 2008. Nucleic Acids Research, 36(Sp. 1), D440-D444. doi: 10.1093/nar/gkm883
2. Barrell D., Dimmer E., Huntley R.P., Binns D., O'Donovan C., Apweiler R. (2009). The GOA database in 2009--an integrated Gene Ontology Annotation resource. Nucleic Acids Research, 37: D396-D403. doi:10.1093/nar/gkn803
3. AMIGO
4. GOA
2. Barrell D., Dimmer E., Huntley R.P., Binns D., O'Donovan C., Apweiler R. (2009). The GOA database in 2009--an integrated Gene Ontology Annotation resource. Nucleic Acids Research, 37: D396-D403. doi:10.1093/nar/gkn803
3. AMIGO
4. GOA
Site created by Valeri Lapacek
Genetics 677 Assignment, Spring 2012
University of Wisconsin-Madison
Last Updated: 5/23/2012
Genetics 677 Assignment, Spring 2012
University of Wisconsin-Madison
Last Updated: 5/23/2012